Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility
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چکیده
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Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition
The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Cardamonin significantly relaxed fluoride-, phenylephrine-, and phorbol ester-induced vascular contractions, ...
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ژورنال
عنوان ژورنال: Digestive Diseases and Sciences
سال: 2016
ISSN: 0163-2116,1573-2568
DOI: 10.1007/s10620-015-4026-9